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An estimate from the doses and published half-lives, not a blood level. Never change a dose or a schedule because of it: ask your prescriber.
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Wegovy half-life calculator: 2.4 mg and 7.2 mg
Wegovy's label gives semaglutide a half-life of about 1 week, so it stays in the body for about 5 to 7 weeks after the last dose. This page opens the half-life calculator on Wegovy® at 2.4 mg, with every injection dose on the Wegovy label, including the 7.2 mg of Wegovy® HD. Enter how many weekly shots you have taken and the time of the last one to see an estimate of the semaglutide in your body and how long it lasts. The estimate comes from label figures, not from a blood test, and it is never a dosing suggestion.
What does the Wegovy label say about its half-life?
The Wegovy prescribing information (§ 12.3) reads: "With an elimination half-life of approximately 1 week, semaglutide will be present in the circulation for about 5 to 7 weeks after the last injectable dose of 2.4 mg or 7.2 mg or oral dose of 25 mg." That one sentence covers the shots, the 7.2 mg dose and the Wegovy pill.
The calculator models the weekly injection with a half-life of 168 hours, as the main half-life calculator page explains. It does not model the Wegovy pill, which is a daily tablet rather than a weekly shot. The dose choices on this page follow § 2.2 of the Wegovy label:
| Wegovy injection dose | Where it sits on the label |
|---|---|
| 0.25 mg, 0.5 mg, 1 mg | The first three 4-week steps |
| 1.7 mg | The fourth step, and a maintenance dose for weight reduction |
| 2.4 mg | The usual recommended maintenance dose |
| 7.2 mg (Wegovy HD) | The maximum, for weight reduction in adults |
The label allows 7.2 mg after at least 4 weeks on 2.4 mg, when more weight reduction is clinically indicated. Whether and when any step happens is the prescriber's decision.
A worked example: 12 weekly shots of 2.4 mg, then 7.2 mg
The doses in this example are illustrative. Someone has taken 12 weekly shots of the same dose and then takes no more. The calculator estimates the amount left at each point after the final shot, for 2.4 mg and for 7.2 mg:
| Time after the last shot | 2.4 mg | 7.2 mg | Share of the peak |
|---|---|---|---|
| 1 day (about the peak) | 3.90 mg | 11.69 mg | 100% |
| 1 week | 2.21 mg | 6.62 mg | 57% |
| 2 weeks | 1.10 mg | 3.31 mg | 28% |
| 3 weeks | 0.55 mg | 1.65 mg | 14% |
| 4 weeks | 0.28 mg | 0.83 mg | 7% |
| 5 weeks | 0.14 mg | 0.41 mg | 4% |
| 6 weeks | 0.07 mg | 0.21 mg | 2% |
| 7 weeks | 0.03 mg | 0.10 mg | 1% |
The 7.2 mg column is three times the 2.4 mg column at every point, give or take the rounding of the last digit. The model adds one curve per shot, each in proportion to its dose, so tripling the dose triples the curve and leaves its shape alone.
How long does Wegovy take to clear?
After that last shot, the calculator puts the amount below 10% of its peak about 25 days later, below 3% after about 37 days and below 1% after about 48 days. Those days sit inside the label's 5 to 7 weeks, which run from day 35 to day 49.
The days are the same for 2.4 mg and 7.2 mg. A higher dose starts from a higher peak, but it loses the same half every week.
What can this estimate not tell you?
- A measured amount. Nobody's blood was tested to draw this curve. Body weight and kidney function move the real figure, and the calculator uses the label's average.
- How the Wegovy pill behaves. The tablets are taken by mouth every day, with label rules about water and food. This page models the injection only.
- Anything about switching doses. Moving between 2.4 mg and 7.2 mg is a decision for the prescriber, made from the label's conditions, not from this estimate.
Frequently asked questions
Does Wegovy HD 7.2 mg stay in the body longer than 2.4 mg?
Not according to the label, which gives the same 5 to 7 weeks after the last dose of either. In the calculator, both fall below 3% of their peak after about 37 days.
Why does Wegovy say 5 to 7 weeks when Ozempic says 5?
Both labels give semaglutide a half-life of about 1 week. The Ozempic label says about 5 weeks in the circulation, and the Wegovy label, which covers higher doses, says 5 to 7 weeks. The Ozempic half-life page uses the same model.
How long does it take to reach a steady level on Wegovy?
The Wegovy label does not state it. The Ozempic label, for the same medicine, says 4 to 5 weeks of weekly shots, and every Wegovy dose step starts that build-up again.
Where are the Wegovy dose steps by week?
The Wegovy dose chart shows each step of the label's schedule, with the maintenance doses marked.
Sources
- Wegovy (semaglutide) prescribing information, DailyMed: half-life and time in the circulation (§ 12.3); injection doses, maintenance doses and 7.2 mg (§ 2.2).
- Ozempic (semaglutide) prescribing information, DailyMed: steady state of semaglutide injection (§ 12.3).
Published by Petros IT Solutions SRL. Read our editorial policy, and send corrections to office@doseandlose.com.